About Silymarin A polyphenolic flavonoid, Hepatoprotective(antihepatotoxic),antioxidant. Mechanism of Action of Silymarin Silymarin stimulates RNA polymerase A and results in an increase in ribosomal protein synthesis and leads to the synthesis of new hepatocytes and also increase the regenerative ability of the liver. It stabilizes the hepatic cell membrane and prevents the penetration of toxin in to the cell and also slows the absorption of harmful substances in to the liver. Silymarin contains antioxidant flavanoid. It combines with free radicals formed from metabolic process and also from breakdown of toxic substances and neutralizes them. Because of its antioxidant action it has anti-inflammatory property and it is used in ulcerative colitis and in ulcers. It increases the glutathione content in the liver and intestine and also increases the activity of super oxide dismutase enzymes and is helpful in detoxifying actions of liver.