About Piperazine A GABA receptor agonist, Anthelmintic -Antinematodal. Mechanism of Action of Piperazine The drug exerts its action by acting as a GABA agonist and causing hyperpolarisation of worm muscle and relaxation and depresses the contractile action of acetyl choline resulting in flaccid paralysis of worms, which are then expelled by peristaltic movements Indications for Piperazine 1. Ascariasis 2. Enterobiasis