About Orphenadrine Anticholinergic(AntiMuscarinic),ethanolamine H1 antagonist, Anti-Parkinson`s Agent,Centrally acting skeletal muscle relaxent. Mechanism of Action of Orphenadrine The exact mechanism of action is not known. A lesion in the Nigra striatum may be responsible for Parkinson`s disease which results in a reduction in Dopamine concentrations. This in turn causes a relative imbalance between dopaminergic and cholinergic neurological pathways. Procyclidine acts by blocking the central muscarinic receptors (M1, M2 and M4 receptors). Thereby it balances cholinergic and dopaminergic action in the basal ganglia. Skeletal muscle relaxant action: It reduces skeletal muscle spasm by its anticholinergic action on cerebral motor centers. Orphenadrine binds to both H1 receptor and NMDA receptors. It restores the motor disturbances induced by Neuroleptics