About Cefoperazone Sodium A third generation cephalosporin antibiotic, Parenteral antibiotic. Mechanism of Action of Cefoperazone Sodium Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis Indications for Cefoperazone Sodium 1.Meningitis 2.Biliary infections 3.Septicemia 4.Infections in immunocompromised patients 5.Urinary tract &genital tract infections 6.Surgical prophylaxis 7.Skin & soft tissue infections 8.Bone & Joint infections 9.Gonorrhea, 10.Peritonitis.