About Cefotaxime Third Generation cephalosporin Parenteral antibiotic. Mechanism of Action of Cefotaxime Cefotaxime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefotaxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefotaxime Indications for Cefotaxime 1.Meningitis 2.Resistant hospital acquired infections 3.Septicemia 4.Infections in immunocompromised patients 5.Urinary tract &genital tract infections 6.Surgical prophylaxis 7.Skin & soft tissue infections 8.Bone & Joint infections 9.Gonorrhea. Interactions for Cefotaxime Synergy with aminoglycosides.