About Fludrocortisone acetate Systemic adrenocortical steroid (mineral corticoid), Organofluoride derivative, Mineral corticoid replacement therapy Mechanism of Action of Fludrocortisone acetate It is a potent mineralocorticoid also having some glucocorticoid action. The drug exerts it`s pharmacological action- in adrenocortical insufficiency by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It enhances the sodium reabsorption in the distal tubule of the kidney.