About Griseofulvin Penicillium antibiotic,Mitotic inhibitor, Oral antifungal. Mechanism of Action of Griseofulvin Griseofulvin is a fungistatic drug. It disorients microtubule and inhibits mitosis especially at metaphase. It actually prevents the separation of the 2 daughter chromosomes. This results in multinucleated and stunted fungal hyphae Indications for Griseofulvin 1.Tinea cruris 2.Tinea capitis 3.Tinea corporis 4.Tinea barbae 5.Tinea unguium 6.Tinea pedis