About Mebendazole A benzimidazole derivative, Anthelmintic. Mechanism of Action of Mebendazole Mebendazole is a benzimidazole used as a broad spectrum anthelminthic which acts by blocking glucose uptake in the parasite and depletion of its glycogen stores. Intracellular microtubules in the cells of the worm are gradually lost. The drug binds to beta tubulin of susceptible worms with high affinity and inhibits its polymerization. Ascaris ova are killed. It also inhibits hatching of nematode eggs and larvae. Indications for Mebendazole 1. Ascariasis 2. Pinworm infection 3. Hook worm infection 4. Tape worm infection 5. Whip worm infections 6. Threadworm infections 7. Hydatid disease 8. Cappillariasis 9. Mixed infestation