About Methocarbamol A centrally acting skeletal muscle relaxant, Carbamate derivative, Skeletal muscle relaxant. Mechanism of Action of Methocarbamol This skeletal muscle relaxant depresses central nervous system by the preferential blockade of spinal and supraspinal polysynaptic reflexes. This leads to sedation and a reduction in skeletal muscle spasms. These effects are accompanied by relief of pain and an increase in the mobility of the affected muscles. Pain relief is postulated to be due to alterations in the perception of pain. About Paracetamol Acetanilide derivative, Non narcotic Analgesic,Antipyretic. Mechanism of Action of Paracetamol Paracetamol has analgesic and antipyretic action. It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis. Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect. Antipyretic action: Paracetamol lowers fever by direct action on the thermoregu