About Cefepime Fourth Generation cephalosporin antibiotic. Mechanism of Action of Cefepime Cefepime is a 3rd generation cephalosporin which exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Cefepime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefipime Indications for Cefepime 1.Pneumonia 2.Resistant hospital acquired infections 3.Septicemia, 4.Empiric therapy in febrile neutropenic patients 5.Urinary tract infections 6.Pyelonephritis 7.Tonsillitis, Pharyngitis etc. 8.Skin & soft tissue infections